Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

@article{Murtaza2013NoninvasiveAO,
  title={Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA},
  author={Muhammed Murtaza and Sarah-Jane Dawson and Dana Wai Yi Tsui and Davina Gale and Tim Forshew and Anna M Piskorz and Christine A. Parkinson and Shin-miao Chin and Zoya Kingsbury and Alvin Seng Cheong Wong and Francesco Marass and Sean J. Humphray and James Hadfield and David W. Bentley and Tan Min Chin and James D. Brenton and Prof Carlos Caldas and Nitzan Rosenfeld},
  journal={Nature},
  year={2013},
  volume={497},
  pages={108-112}
}
Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection. Repeat biopsies to study genomic evolution as a result of therapy are difficult, invasive and may be confounded by intra-tumour heterogeneity. Recent studies have shown that genomic alterations in solid cancers can be characterized by massively parallel sequencing of circulating cell-free tumour DNA released from cancer cells into plasma, representing a non-invasive liquid biopsy. Here we report… CONTINUE READING
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