Non-invasive amino acid turnover predicts human embryo developmental capacity.

@article{Houghton2002NoninvasiveAA,
  title={Non-invasive amino acid turnover predicts human embryo developmental capacity.},
  author={Franchesca D. Houghton and Judith A. Hawkhead and Peter G. Humpherson and J Hogg and Adam H Balen and Anthony J. Rutherford and Henry J. Leese},
  journal={Human reproduction},
  year={2002},
  volume={17 4},
  pages={
          999-1005
        }
}
BACKGROUND IVF is limited by low success rates and a confounding high multiple birth rate contributing to prematurity, increased neonatal mortality and child handicap. These problems could be overcome if single embryos of known developmental competence could be selected for transfer on day 2/3 of development, but current methods, which rely on morphological appearance, are poor predictors of viability. METHODS We have measured non-invasively the depletion/appearance (i.e. turnover) of a… Expand
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