Non-interaction of spironolactone medication and cortisol metabolism in man

@article{Abshagen2005NoninteractionOS,
  title={Non-interaction of spironolactone medication and cortisol metabolism in man},
  author={U. Abshagen and S. Sp{\"o}rl and M. L'age},
  journal={Klinische Wochenschrift},
  year={2005},
  volume={56},
  pages={135-138}
}
ZusammenfassungBei 5 gesunden Probanden und bei 5 Patienten mit dekompensierten Lebererkrankungen wurden die Konzentrationen von Cortisol und von Canrenon und Canrenoat-K im Plasma nach jeweils einer Einzeldosis von 7 mg Spironolakton/kg mit und ohne 12tägiger Vorbehandlung mit Spironolakton über jeweils 4 Tage verfolgt. Die Bestimmung der Spironolaktonmetabolite erfolgte fluorimetrisch. Das Cortisol im Plasma wurde mit einem hochspezifischen Radioimmunoassay mit vorgeschalteter… Expand
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