Non-infectious morphologically altered nucleocapsids of measles virus from persistently infected cells

@article{Andzhaparidze2005NoninfectiousMA,
  title={Non-infectious morphologically altered nucleocapsids of measles virus from persistently infected cells},
  author={O. G. Andzhaparidze and N. M. Chaplygina and N. Bogomolova and V. Lotte and I. B. Koptyaeva and Y. S. Boriskin},
  journal={Archives of Virology},
  year={2005},
  volume={95},
  pages={17-28}
}
SummaryPersistent measles virus infection of human HEp-2 or L-41 cells was accompanied by pronounced structural and functional changes of isolated intracellular viral nucleocapsids (NCs). The bulk of persistent NCs possessed altered conformation and a “string-of-beads” appearance, contained substantial amounts of subgenomic size RNAs, exhibited reduced transcriptase activityin vitro and lacked infectivity on transfection of susceptible cells. Immunogold staining revealed negligible binding of… Expand

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