Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.

@article{Moroder2009NonhydrolyzableRC,
  title={Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.},
  author={Holger Moroder and Jessica Steger and Dagmar Graber and Katja Fauster and Krista Trappl and Viter M{\'a}rquez and Norbert Polacek and Daniel N. Wilson and Ronald Micura},
  journal={Angewandte Chemie},
  year={2009},
  volume={48 22},
  pages={4056-60}
}
Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to… CONTINUE READING