Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions.

Abstract

XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that repairs DNA DSBs (double-strand breaks). The individual crystal structures show that the dimeric proteins are homologues with protomers containing head domains and helical coiled-coil… (More)
DOI: 10.1042/BST0391387

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