Non-homologous end joining as an important mutagenic process in cell cycle-arrested cells.

@article{Heidenreich2003NonhomologousEJ,
  title={Non-homologous end joining as an important mutagenic process in cell cycle-arrested cells.},
  author={Erich Heidenreich and Ren{\'e} Novotny and Bernd Kneidinger and Veronika Holzmann and Ulrike Wintersberger},
  journal={The EMBO journal},
  year={2003},
  volume={22 9},
  pages={2274-83}
}
Resting cells experience mutations without apparent external mutagenic influences. Such DNA replication-independent mutations are suspected to be a consequence of processing of spontaneous DNA lesions. Using experimental systems based on reversions of frameshift alleles in Saccharomyces cerevisiae, we evaluated the impact of defects in DNA double-strand break (DSB) repair on the frequency of replication-independent mutations. The deletion of the genes coding for Ku70 or DNA ligase IV, which are… CONTINUE READING