Non-homologous DNA end joining in the mature rat brain.

  title={Non-homologous DNA end joining in the mature rat brain.},
  author={Keqin Ren and Sandra Pe{\~n}a de Ort{\'i}z},
  journal={Journal of neurochemistry},
  volume={80 6},
Recent evidence suggests that DNA double strand breaks (DSBs) are introduced in neurons during the course of normal development, and that repair of such DSBs is essential for neuronal survival. Here we describe a non-homologous DNA end joining (NHEJ) system in the adult rat brain that may be used to repair DNA DSBs. In the brain NHEJ system, blunt DNA ends are joined with lower efficiency than cohesive or non-matching protruding ends. Moreover, brain NHEJ is blocked by DNA ligase inhibitors or… CONTINUE READING

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