Non-histone protein methylation as a regulator of cellular signalling and function

  title={Non-histone protein methylation as a regulator of cellular signalling and function},
  author={Kyle K. Biggar and Shawn S.-C. Li},
  journal={Nature Reviews Molecular Cell Biology},
  • K. Biggar, S. Li
  • Published 2015
  • Biology
  • Nature Reviews Molecular Cell Biology
Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK–STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein… 
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