Non-hemolytic α-AApeptides as antimicrobial peptidomimetics.


We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics. 
DOI: 10.1039/c1cc13684d


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