Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

@article{Ozer2007NonhemeDC,
  title={Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?},
  author={Abdullah Ozer and Richard K. Bruick},
  journal={Nature chemical biology},
  year={2007},
  volume={3 3},
  pages={144-53}
}
Members of the Fe(II)- and 2-oxoglutarate-dependent family of dioxygenases have long been known to oxidize several amino acids in various protein targets to facilitate protein folding. However, in recent years investigators have characterized several such hydroxylation modifications that serve a regulatory, rather than structural, purpose. Furthermore, the responsible enzymes seem to function directly as sensors of the cellular environment and metabolic state. For example, a cellular response… CONTINUE READING

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