Non-globular Domains in Protein Sequences: Automated Segmentation Using Complexity Measures

@article{Wootton1994NonglobularDI,
  title={Non-globular Domains in Protein Sequences: Automated Segmentation Using Complexity Measures},
  author={John C. Wootton},
  journal={Computers & chemistry},
  year={1994},
  volume={18 3},
  pages={269-85}
}
Computational methods based on mathematically-defined measures of compositional complexity have been developed to distinguish globular and non-globular regions of protein sequences. Compact globular structures in protein molecules are shown to be determined by amino acid sequences of high informational complexity. Sequences of known crystal structure in the Brookhaven Protein Data Bank differ only slightly from randomly shuffled sequences in the distribution of statistical properties such as… CONTINUE READING
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