Non-germ Line Restoration of Genomic Imprinting for a Small Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem Cells*

@article{Qi2015NongermLR,
  title={Non-germ Line Restoration of Genomic Imprinting for a Small Subset of Imprinted Genes in Ubiquitin-like PHD and RING Finger Domain-Containing 1 (Uhrf1) Null Mouse Embryonic Stem Cells*},
  author={Shankang Qi and Zhiqiang Wang and Pishun Li and Qihan Wu and Tieliu Shi and Jiwen Li and Jiemin Wong},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={14181 - 14191}
}
Background: Once erased, DNA methylation in imprinted genes was shown previously to be re-established only through germ line passage. Results: UHRF1 re-expression in Uhrf1−/− mouse embryonic stem (ES) cells restores DNA methylation for a few imprinted genes. Conclusion: DNA methylation in a few imprinted genes can be restored without germ line passage. Significance: ES cells can be a useful model for studying DNA methylation establishment in imprinted genes. The underlying mechanism for the… CONTINUE READING

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