Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.

@article{Roberts1995NongenotoxicHS,
  title={Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.},
  author={R. Roberts and A. Soames and J. Gill and N. James and E. Wheeldon},
  journal={Carcinogenesis},
  year={1995},
  volume={16 8},
  pages={
          1693-8
        }
}
Non-genotoxic hepatocarcinogenesis may involve suppression of the hepatocyte apoptosis that would normally remove damaged or initiated cells. These protected hepatocytes could then remain as preferential targets for promotion by this class of compounds. Here we demonstrate clearly that the non-genotoxic liver carcinogens and hepatomitogens cyproterone acetate (CPA) and nafenopin, a peroxisome proliferator, both suppress the basal level of rat liver apoptosis in vivo. After 10 days of dosing… Expand
Involvement of hepatocyte growth factor on hepatocarcinogenesis induced by peroxisome proliferators
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo
The perturbation of apoptosis and mitosis by drugs and xenobiotics.
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