Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones

@article{Fujinoki2015NongenomicRA,
  title={Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones},
  author={Masakatsu Fujinoki and Gen L. Takei and Hiroe Kon},
  journal={The Journal of Physiological Sciences},
  year={2015},
  volume={66},
  pages={207-212}
}
During capacitation, motility of mammalian spermatozoon is changed from a state of “activation” to “hyperactivation.” Recently, it has been suggested that some hormones present in the oviduct are involved in the regulation of this hyperactivation in vitro. Progesterone, melatonin, and serotonin enhance hyperactivation through specific membrane receptors, and 17β-estradiol suppresses this enhancement by progesterone and melatonin via a membrane estrogen receptor. Moreover, γ-aminobutyric acid… 
View on Springer
ncbi.nlm.nih.gov
23 Citations
Background Citations
7

23 Citations

Pre-Treatment of Swine Oviductal Epithelial Cells with Progesterone Increases the Sperm Fertilizing Ability in an IVF Model
TLDR
It is demonstrated that oviductal epithelial cells (OECs) pre-treated with progesterone (P4) at 100 ng/mL represent the ideal environment for sperm capacitation, inducing a positive effect on the sperm acquisition of the fertilizing ability.
Steroid hormones regulate sperm-oviduct interactions in the bovine.
TLDR
The hypothesis that the dynamic changes in steroid hormones around the time of ovulation regulate the formation of the sperm reservoir and the timed delivery of capacitated spermatozoa to the site of fertilization is supported.
Regulation of hamster sperm hyperactivation by extracellular
TLDR
The results suggest that extracellular Na+ suppresses hamster sperm hyperactivation by reducing intracellular Ca2+ via an action of NCX in a tyrosine phosphorylation-independent manner, and it seems that the removal of suppression by extrace cellular Na+ leads to the expression of hyperactivated motility.
Regulation of hamster sperm hyperactivation by extracellular Na.
TLDR
The results suggest that extracellular Na(+) suppresses hamster sperm hyperactivation by reducing intracellular Ca(2+) via an action of NCX in a tyrosine phosphorylation-independent manner.
γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine
TLDR
It is demonstrated that hamster sperm hyperactivation is regulated by an interaction between the 5HT2 receptor-mediated action of 5HT and GABA.
Oviductal high concentration of K+ suppresses hyperpolarization but does not prevent hyperactivation, acrosome reaction and in vitro fertilization in hamsters
TLDR
It is confirmed that, in hamster sperm, membrane potential wasHyperpolarized upon in vitro capacitation, indicating that capacitation-associated hyperpolarization is a universal phenomenon among mammalian species.
Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice
TLDR
5-HT increased hyperactivation through the 5-HT receptors and increased the success of IVF in mice, suggesting that the effects of 5-hydroxytryptamine on the motility and hyperactivation of mouse spermatozoa are examined.
Serotonergic signals enhanced hamster sperm hyperactivation
TLDR
Investigation of the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters found that under the condition that sperm are hyperactivated, 5-HT likely stimulates PLC/IP3 receptor signals via the 5- HT2A receptor and tmAC/PKA/CatSper channel signals viaThe 5-ht4 receptor.
Regulation of the bovine oviductal fluid proteome.
TLDR
This work identifies numerous new candidate proteins potentially interacting with the oocyte, spermatozoa and embryo to modulate fertilization and early embryo development.
Supplementation of 17β-estradiol and progesterone in the co-culture medium of bovine oviductal epithelial cells and ovine spermatozoa reduces the sperm kinematics and capacitation.
...
...

References

SHOWING 1-10 OF 76 REFERENCES
Regulation of hyperactivation of hamster spermatozoa by progesterone
TLDR
It is likely that P regulates sperm hyperactivation by a non-genomic signal in relation to tyrosine phosphorylation and PLC.
Human spermatozoa as a model for studying membrane receptors mediating rapid nongenomic effects of progesterone and estrogens
Nongenomic activation of spermatozoa by steroid hormones: Facts and fictions
Nongenomic effects of progesterone on spermatozoa: mechanisms of signal transduction and clinical implications.
TLDR
Sperm responsiveness to progesterone is impaired in subfertile patients and is strictly correlated to the ability of fertilize the oocyte, and can be clinically useful for the preliminary assessment of the male partner to select the appropriate assisted reproductive technique.
Hyperactivation of mammalian spermatozoa: function and regulation.
TLDR
Although hyperactivation usually occurs during capacitation, the two events are regulated by different pathways and may also involve increases in intracellular cAMP, which at least is required to support motility in general.
Suppression of Progesterone-enhanced Hyperactivation in Hamster Spermatozoa by γ-aminobutyric Acid
TLDR
Although sperm hyperactivation was enhanced by P, GABA significantly suppressed P-enhanced hyperactivation in a dose-dependent manner and P bound to the sperm head, and this binding was decreased by GABA.
Non-genomic regulation of mammalian sperm hyperactivation
  • M. Fujinoki
  • Biology
    Reproductive medicine and biology
  • 2009
TLDR
The concentration of many hormones changes according to environmental conditions and biological rhythms, which will modulate ligand-dependent regulation of hyperactivation, and Progesterone and melatonin have been identified as ligands that regulate hyperactivation.
Studies related to progesterone‐induced hamster sperm acrosome reaction
TLDR
Results suggest that progesterone acts on the hamster sperm plasma membrane to stimulate exocytosis, which requires external Ca2+ and presumably Ca2- influx, and a sperm trypsin like protease may be part of the mechanism by which progester one stimulates AR.
Progesterone activates the principal Ca2+ channel of human sperm
TLDR
It is found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca2+ channel of the sperm flagellum, which represents a promising target for the development of a new class of non-hormonal contraceptives.
Progesterone-enhanced sperm hyperactivation through IP3–PKC and PKA signals
  • M. Fujinoki
  • Biology
    Reproductive medicine and biology
  • 2013
TLDR
The results suggest that progesterone-enhanced sperm hyperactivation occurs through two signal pathways: an intracellular Ca2+ signal through production of IP3 and DAG by PLC, binding of IP 3 to IP3R and activation of PKC by DAG and Ca2+.
...
...