Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones

@article{Fujinoki2015NongenomicRA,
  title={Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones},
  author={Masakatsu Fujinoki and Gen L. Takei and Hiroe Kon},
  journal={The Journal of Physiological Sciences},
  year={2015},
  volume={66},
  pages={207-212}
}
During capacitation, motility of mammalian spermatozoon is changed from a state of “activation” to “hyperactivation.” Recently, it has been suggested that some hormones present in the oviduct are involved in the regulation of this hyperactivation in vitro. Progesterone, melatonin, and serotonin enhance hyperactivation through specific membrane receptors, and 17β-estradiol suppresses this enhancement by progesterone and melatonin via a membrane estrogen receptor. Moreover, γ-aminobutyric acid… 
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TLDR
5-HT increased hyperactivation through the 5-HT receptors and increased the success of IVF in mice, suggesting that the effects of 5-hydroxytryptamine on the motility and hyperactivation of mouse spermatozoa are examined.
Serotonergic signals enhanced hamster sperm hyperactivation
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Investigation of the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters found that under the condition that sperm are hyperactivated, 5-HT likely stimulates PLC/IP3 receptor signals via the 5- HT2A receptor and tmAC/PKA/CatSper channel signals viaThe 5-ht4 receptor.
Regulation of the bovine oviductal fluid proteome.
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This work identifies numerous new candidate proteins potentially interacting with the oocyte, spermatozoa and embryo to modulate fertilization and early embryo development.
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