Non-genomic loss of PTEN function in cancer: not in my genes.

Abstract

Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to classical models of tumour suppression, partial loss of PTEN function appears to be frequently observed in the clinic. In addition, studies of both humans and mice with reductions in PTEN gene dosage… (More)
DOI: 10.1016/j.tips.2010.12.005

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