Non-genomic glucocorticoid effects to provide the basis for new drug developments

@article{Song2006NongenomicGE,
  title={Non-genomic glucocorticoid effects to provide the basis for new drug developments},
  author={In-Ho Song and Frank Buttgereit},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={246},
  pages={142-146}
}
Glucocorticoids act via genomic and non-genomic actions. The genomic glucocorticoid actions are well known and new details on processes of transactivation and transrepression have been reported recently. Here we describe the current knowledge on non-genomic glucocorticoid actions and discuss why these actions are considered to be of therapeutic relevance. It is assumed that rapid non-genomic glucocorticoid effects are mediated by three different mechanisms: (1) physicochemical interactions with… Expand

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