Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

@article{Brock2009NongeneticH,
  title={Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours},
  author={Amy Lepre Brock and Hannah Ya-Ning Chang and Sui Huang},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={336-342}
}
Clonal populations of mammalian cells are inherently heterogeneous. They contain cells that display non-genetic variability resulting from gene expression noise and the fact that gene networks have multiple stable states. These stable, heritable variants within one cell type can exhibit different levels of responsiveness to environmental conditions. Hence… CONTINUE READING