Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels.

@article{Sainsbury2004NonesterifiedFA,
  title={Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels.},
  author={Christopher Sainsbury and Naveed Sattar and John M. Connell and Chris Hillier and John R. Petrie},
  journal={Clinical science},
  year={2004},
  volume={107 6},
  pages={
          625-9
        }
}
Elevated circulating levels of NEFAs (non-esterified fatty acids) are associated with states of insulin resistance and increased risk of vascular disease. Previous animal and human studies have demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-dependent vasodilation of rat resistance arteries in vitro using the technique of wire myography. In… 

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