Non-enzymic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione.

Radioactive galactose becomes attached covalently to lens proteins in the same way as glucose. Simultaneous incubation with aspirin inhibits the reaction with galactose in a dose-related manner. Incubation with aspirin before incubation with galactose in the absence of aspirin showed that aspirin can modify crystallins permanently to prevent the binding of… CONTINUE READING