Non-enzymic copper reduction by menaquinone enhances copper toxicity in Lactococcus lactis IL1403.

@article{Abicht2013NonenzymicCR,
  title={Non-enzymic copper reduction by menaquinone enhances copper toxicity in Lactococcus lactis IL1403.},
  author={Helge K. Abicht and Yulia Gonskikh and Simon D Gerber and Marc Solioz},
  journal={Microbiology},
  year={2013},
  volume={159 Pt 6},
  pages={1190-7}
}
Lactococcus lactis possesses a pronounced extracellular Cu(2+)-reduction activity which leads to the accumulation of Cu(+) in the medium. The kinetics of this reaction were not saturable by increasing copper concentrations, suggesting a non-enzymic reaction. A copper-reductase-deficient mutant, isolated by random transposon mutagenesis, had an insertion in the menE gene, which encodes O-succinylbenzoic acid CoA ligase. This is a key enzyme in menaquinone biosynthesis. The ΔmenE mutant was… CONTINUE READING

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