Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

@article{Yan1995NonenzymaticallyGT,
  title={Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide},
  author={Shirley ShiDu Yan and Shi Fang Yan and Xin Chen and Jiamei Fu and Ming Huei Chen and Periannan Kuppusamy and Mark A. Smith and George Perry and Gabriel C. Godman and Peter P Nawroth and Jay L. Zweier and David Stern},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={693-699}
}
Paired helical filament (PHF) tau is the principal component of neurofibriliary tangles, a characteristic feature of the neurodegenerative pathology in Alzheimer's disease (AD). Post-translational modification of tau, especially phosphorylation, has been considered a major factor in aggregation and diminished microtubule interactions of PHF-tau. Recently, it has been recognized that PHF-tau is also subject to non-enzymatic glycation, with formation of advanced glycation end products (AGEs). We… CONTINUE READING

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