Non-enzymatic transcription of an oligodeoxynucleotide 14 residues long.

@article{Acevedo1987NonenzymaticTO,
  title={Non-enzymatic transcription of an oligodeoxynucleotide 14 residues long.},
  author={O. Acevedo and L. Orgel},
  journal={Journal of molecular biology},
  year={1987},
  volume={197 2},
  pages={
          187-93
        }
}
The 14-mer oligodeoxynucleotide d(C3GC3GC3GC2) acts as a template to facilitate the cooligomerization of guanosine 5'-phospho-2-methylimidazolide and cytidine 5'-phospho-2-methylimidazolide. The predominant products are a series of 3'-5'-linked oligonucleotides, complementary to the template, ranging in length from GGC to GGCGGGCGGGCGGG. Thus simple, non-enzymatic template-directed reactions can result in the accurate transfer of substantial amounts of information from template to products. The… Expand
34 Citations
Preference for Internucleotide Linkages as a Function of the Number of Constituents in a Mixture
The limits of template-directed synthesis with nucleoside-5′-phosphoro(2-methyl)imidazolides
Chemical self-replication of palindromic duplex DNA
The origin of polynucleotide-directed protein synthesis
  • L. Orgel
  • Biology, Medicine
  • Journal of Molecular Evolution
  • 2007
Prebiotic chemistry and the origin of the RNA world.
  • L. Orgel
  • Biology, Medicine
  • Critical reviews in biochemistry and molecular biology
  • 2004
A modified cellular automata model of nucleotide interactions and non-enzymatic transcription of DNA
The binding and reactions of nucleotides and polynucleotides on iron oxide hydroxide polymorphs
...
1
2
3
4
...

References

SHOWING 1-7 OF 7 REFERENCES
Template-directed synthesis on the oligonucleotide d(C7-G-C7).
Template-directed synthesis on the pentanucleotide CpCpGpCpC.
A nonenzymatic RNA polymerase model.
Mapping adenines, guanines, and pyrimidines in RNA.