Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

@article{Joyce1984NonenzymaticTS,
  title={Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.},
  author={G. F. Joyce and T. Inoue and L. Orgel},
  journal={Journal of molecular biology},
  year={1984},
  volume={176 2},
  pages={
          279-306
        }
}
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for both monomers as the uracil content of the template increases. The relatively poor incorporation of adenine is partly due to an intrinsically less efficient incorporation reaction, and partly due to the masking of… Expand
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