Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates.

@article{Joyce1984NonenzymaticTS,
  title={Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates.},
  author={G. F. Joyce and L. Orgel},
  journal={Journal of molecular biology},
  year={1984},
  volume={202 3},
  pages={
          677-81
        }
}
Poly(C,A) random copolymer templates direct the oligomerization of 2-MeImpG (2-MeImpX is the 5'-phospho-2-methylimidazolide of the nucleoside X) and 2-MeImpU, resulting in the production of a variety of oligo (G,U)s. This reaction is less efficient than comparable reactions involving poly(C,U) or poly(C,G) templates. The efficiency of monomer incorporation into newly synthesized oligomers is lower for 2-MeImpU than 2-MeImpG, and cannot be improved by increasing the concentration of 2-MeImpU… Expand
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