Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis.

@article{Hollmann2006NonenzymaticRO,
  title={Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis.},
  author={Frank Hollmann and Karin Hofstetter and Andreas Schmid},
  journal={Trends in biotechnology},
  year={2006},
  volume={24 4},
  pages={163-71}
}
Biocatalytic oxygenation chemistry is a rapidly evolving field in which monooxygenases are the tools of choice. Monooxygenases catalyze many industrially important synthetic transformations; however, their use in preparative applications is hampered by their intrinsic requirement for reducing equivalents. As a result, non-enzymatic strategies--where the reducing equivalents are introduced directly into the catalytic cycle--are being developed to supersede the well-established enzymatic NAD(P)H… CONTINUE READING