Non-enzymatic glycation enhances human serum albumin binding capacity to sodium fluorescein at room temperature: A spectroscopic analysis.

@article{Fatima2017NonenzymaticGE,
  title={Non-enzymatic glycation enhances human serum albumin binding capacity to sodium fluorescein at room temperature: A spectroscopic analysis.},
  author={Sadaf Fatima and Tamanna Anwar and Nabeel Ahmad and Asimul Islam and Priyankar Sen},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2017},
  volume={469},
  pages={
          180-186
        }
}
BACKGROUND Sodium fluorescein (SF) is a fluorescent tracer dye used extensively in diagnostic tools in the field of Ophthalmology, particularly in intravenous fluorescein angiography (IVFA). The binding of SF to human serum albumin (HSA) has been predicted by molecular docking and investigated by circular dichroism (CD) and fluorescence spectroscopy with or without glycation at temperatures 296, 301, and 310K. METHODS The binding parameters were calculated by quenching of emission spectrum of… CONTINUE READING
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