Non-effective dose of exogenously applied L-dopa itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats.

@article{Nakamura1994NoneffectiveDO,
  title={Non-effective dose of exogenously applied L-dopa itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats.},
  author={Shin Nakamura and Jianying Yue and Yoshio Goshima and Takeaki Miyamae and Hiroshi Ueda and Yoshimi Misu},
  journal={Neuroscience letters},
  year={1994},
  volume={170 1},
  pages={22-6}
}
We attempted to clarify whether or not under inhibition of central dopa decarboxylase non-effective i.p. doses of L-dopa potentiate D2 receptor-mediated locomotor activities without conversion to dopamine in normal and i.v.t. 6-hydroxydopamine-treated rats. In normal rats, only the highest dose of quinpirole, a selective D2 agonist, at ranges used (0.01-1 mg/kg, s.c.) slightly increased the total counts of locomotor activities for 140 min after injection. A simultaneously injected non-effective… CONTINUE READING

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