Non-disjunction of chromosome 18.

@article{Bugge1998NondisjunctionOC,
  title={Non-disjunction of chromosome 18.},
  author={Merete Bugge and Andrew Collins and Michael Bjorn Petersen and Jenelle Fisher and Conxita Brandt and Jens Michael Hertz and Lisbeth Tranebjaerg and C de Lozier-Blanchet and Phedon Nicolaides Phedon Nicolaides and Karen Br{\o}ndum-Nielsen and Nicholas M Morton and Margareta Mikkelsen},
  journal={Human molecular genetics},
  year={1998},
  volume={7 4},
  pages={
          661-9
        }
}
A sample of 100 trisomy 18 conceptuses analysed separately and together with a published sample of 61 conceptuses confirms that an error in maternal meiosis II (MII) is the most frequent cause of non-disjunction for chromosome 18. This is unlike all other human trisomies that have been studied, which show a higher frequency in maternal meiosis I (MI). Maternal MI trisomy 18 shows a low frequency of recombination in proximal p and medial q, but not the reduction in proximal q observed in… CONTINUE READING

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