Non-damaging retinal phototherapy: dynamic range of heat shock protein expression.

@article{Sramek2011NondamagingRP,
  title={Non-damaging retinal phototherapy: dynamic range of heat shock protein expression.},
  author={Christopher K Sramek and Mark A. Mackanos and Ryan Spitler and Loh-Shan Bryan Leung and Hiroyuki Nomoto and Christopher H. Contag and Daniel V. Palanker},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 3},
  pages={
          1780-7
        }
}
PURPOSE Subthreshold retinal phototherapy demonstrated clinical efficacy for the treatment of diabetic macular edema without visible signs of retinal damage. To assess the range of cellular responses to sublethal hyperthermia, expression of the gene encoding a 70 kDa heat shock protein (HSP70) was evaluated after laser irradiation using a transgenic reporter mouse. METHODS One hundred millisecond, 532 nm laser exposures with 400 μm beam diameter were applied to the retina surrounding the… CONTINUE READING

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