Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery.

@article{Lomas2008NoncytotoxicPV,
  title={Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery.},
  author={Hannah Lomas and Marzia Massignani and Khairuddin A Abdullah and Irene Cant{\'o}n and Caterina Lo Presti and Sheila MacNeil and Jianzhong Du and Adam Blanazs and Jeppe Madsen and Steven P Armes and Andrew L Lewis and Giuseppe Battaglia},
  journal={Faraday discussions},
  year={2008},
  volume={139},
  pages={
          143-59; discussion 213-28, 419-20
        }
}
We have recently achieved efficient cytosolic delivery by using pH-sensitive poly(2-(methacryloyloxy)ethylphosphorylcholine)-co-poly(2-(diisopropylamino)ethylmethacrylate) (PMPC-PDPA) diblock copolymers that self-assemble to form vesicles, known as polymersomes, in aqueous solution. It is particularly noteworthy that these diblock copolymers form stable polymersomes at physiological pH but rapidly dissociate below pH 6 to give molecularly-dissolved copolymer chains (unimers). These PMPC-PDPA… CONTINUE READING

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