Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes.

  title={Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes.},
  author={Deepak Suri and Ralf Schilling and Agnel R Lopes and Ivana Mullerova and G. P. Colucci and Roger Williams and Nikolai V. Naoumov},
  journal={Journal of hepatology},
  volume={35 6},
BACKGROUND/AIMS Interferon-gamma (IFN-gamma) has been shown to abolish hepatitis B virus (HBV) gene expression and replication in HBV transgenic mice without destroying infected hepatocytes. We investigated the characteristics of IFN-gamma induced non-cytolytic inhibition of viral replication in human HBV infection. METHODS We used an in vitro model where lymphocytes from 15 HBsAg positive patients were co-cultured with transfected hepatocytes supporting HBV replication. The effector and… CONTINUE READING


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