Non-culture diagnosis and serogroup determination of meningococcal B and C infection by a sialyltransferase (siaD) PCR ELISA.

@article{Borrow1997NoncultureDA,
  title={Non-culture diagnosis and serogroup determination of meningococcal B and C infection by a sialyltransferase (siaD) PCR ELISA.},
  author={Ray Borrow and Heike Claus and Malcolm Guiver and L M Smart and D Martin Jones and Edward B. Kaczmarski and Matthias Frosch and Andrew J. Fox},
  journal={Epidemiology and infection},
  year={1997},
  volume={118 2},
  pages={111-7}
}
Rapid, non-culture, serogroup determination of meningococcal infection is important in contact management where vaccination may be possible. The impending availability of polysaccharide-protein conjugate vaccines for serogroup C disease requires maximal case ascertainment, with serogroup determination, at a time when the number of culture confirmed meningococcal infections is decreasing. A polymerase chain reaction assay (PCR), based on a restriction fragment length polymorphism (RFLP) in the… CONTINUE READING

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