Non-covalent versus covalent control of self-assembly and chirality of Nile red-modified nucleoside and DNA.

@article{Varghese2010NoncovalentVC,
  title={Non-covalent versus covalent control of self-assembly and chirality of Nile red-modified nucleoside and DNA.},
  author={Reji Varghese and Hans-Achim Wagenknecht},
  journal={Chemistry},
  year={2010},
  volume={16 30},
  pages={9040-6}
}
A DNA-based covalent versus a non-covalent approach is demonstrated to control the optical, chirooptical and higher order structures of Nile red (Nr) aggregation. Dynamic light scattering and TEM studies revealed that in aqueous media Nr-modified 2'-deoxyuridine aggregates through the co-operative effect of various non-covalent interactions including the hydrogen bonding ability of the nucleoside and sugar moieties and the pi-stacking tendency of the highly hydrophobic dye. This results in the… CONTINUE READING