Non-coordinate control of bone formation displayed by growth factor combinations with IGF-I.

  title={Non-coordinate control of bone formation displayed by growth factor combinations with IGF-I.},
  author={William V Giannobile and S W Whitson and Samuel Lynch},
  journal={Journal of dental research},
  volume={76 9},
Polypeptide growth factors (GFs) promote osteogenesis by enhancing the mitogenesis, migration, and matrix synthesis of osteoblasts. Most previous investigators have evaluated only the effects of single GFs on these parameters. Studies on single GFs might overlook large biological responses comparable with those documented in the cell cycle literature when GFs are used in combinations that interact synergistically. In this study, we screened for synergistic interactions between IGF-I and three… CONTINUE READING

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