Non-cooperative binding of the MAP-2 microtubule-binding region to microtubules.

  title={Non-cooperative binding of the MAP-2 microtubule-binding region to microtubules.},
  author={R L Coffey and Daniel Lee Purich},
  journal={The Journal of biological chemistry},
  volume={270 3},
Microtubule-associated protein (MAP)-2 is a multi-domain cytoskeletal protein that copurifies with brain microtubules (MTs) through repeated cycles of warm polymerization and cold disassembly. Recent equilibrium binding studies of high molecular weight MAP-2ab to taxol-stabilized MTs suggest that the interactions are highly cooperative, as indicated by sigmoidal binding curves, non-linear Scatchard plots, and an apparent all-or-none response in MAP binding in titration experiments (Wallis, K. T… CONTINUE READING


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