Non-convulsive status epilepticus associated with tiagabine in a pediatric patient.


We report a 4-year-old patient who developed non-convulsive status epilepticus (NCSE) following tiagabine (TGB) as add-on treatment for refractory partial seizures. NCSE occurred while the patient received TGB 0.83 mg/kg/day. In our case, the TGB reduction led to a significant improvement of electroclinical features. The mechanisms of this abnormal effect are not clear. GABA-ergic hyperfunction and/or multiplicity of interlinked brain GABA systems associated with individual specific sensitivity could play a critical role in the pathogenesis of NCSE. This is the first report of NCSE documented by electroencephalogram (EEG) in a child under 12 years of age on TGB treatment.


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@article{Mangano2003NonconvulsiveSE, title={Non-convulsive status epilepticus associated with tiagabine in a pediatric patient.}, author={Salvatore Mangano and Liberia Cusumano and Antonina Fontana}, journal={Brain & development}, year={2003}, volume={25 7}, pages={518-21} }