Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure.

@article{Ng2002NoncompetitiveIA,
  title={Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure.},
  author={Leong Loke Ng and Russell J. O'brien and Bettina Demme and Sonja Jennings},
  journal={Clinical science},
  year={2002},
  volume={102 4},
  pages={
          411-6
        }
}
Cardiotrophin-1 (CT-1) leads to a specific form of ventricular hypertrophy characterized by sarcomeres added in series, and has been reported to be elevated in heart failure. Previous competitive assays for CT-1 necessitate the extraction of plasma and involve prolonged incubations. We describe the development of a non-competitive assay for CT-1 that can measure plasma levels without the need for extraction. Two antibodies specific for the mid-section (amino acids 105-120) and C-terminal (amino… CONTINUE READING

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