Non-competitive antagonists of excitatory amino acid receptors

@article{Kemp1987NoncompetitiveAO,
  title={Non-competitive antagonists of excitatory amino acid receptors},
  author={J. Kemp and A. Foster and E. Wong},
  journal={Trends in Neurosciences},
  year={1987},
  volume={10},
  pages={294-298}
}
Abstract Non-competitive antagonists have become important tools for investigating the basic mechanisms of NMDA receptor function. Such compounds (e.g. MK-801, PCP) are thought to act at the level of the NMDA receptor-associated ion channel and many show a marked use-dependence in their antagonist properties. Little information is available concerning selective non-competitive antagonists of quisqualate or kainate receptors. A number of structurally diverse compounds act as non-competitive… Expand
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