• DOI:10.1073/pnas.0807282106
Corpus ID: 24518035

Non-competitive androgen receptor inhibition in vitro and in vivo

@article{Jones2009NoncompetitiveAR,
  title={Non-competitive androgen receptor inhibition in vitro and in vivo},
  author={J. O. Jones and Eric C Bolton and Y. Huang and Cl{\'e}mentine F{\'e}au and R. Guy and K. Yamamoto and B. Hann and M. Diamond},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={7233 - 7238}
}

• J. O. Jones, Eric C Bolton, +5 authors M. Diamond
• Published 2009
• Biology, Medicine
• Proceedings of the National Academy of Sciences

Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available anti-androgens target only ligand binding, either by reduction of available hormone or by competitive antagonism. New strategies are needed, and could have an important impact on therapy. One approach could be to target other cellular mechanisms required for receptor activation. In prior work, we used a cell-based assay of AR… Expand

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