Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.

  title={Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.},
  author={Clement A. Meseda and Kandadai Srinivasan and Jasen Lee Wise and Jennifer G. Catalano and Kenneth M Yamada and Subhash Dhawan},
  journal={Biochemical and biophysical research communications},
  volume={454 1},
Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. Although the functions of many snRNAs remain undetermined, a population of snRNAs is produced during the early phase of infection of cells by vaccinia virus. In the present study, we demonstrate a direct correlation between expression of the cytoprotective enzyme heme oxygenase-1 (HO-1), suppression of selective snRNA expression, and inhibition of vaccinia virus infection of macrophages. Hemin induced HO-1… CONTINUE READING
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