Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome.

@article{Benetatos2013NoncodingRA,
  title={Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome.},
  author={Leonidas Benetatos and Evangelos Voulgaris and George Vartholomatos and Eleftheria Hatzimichael},
  journal={International journal of cancer},
  year={2013},
  volume={133 2},
  pages={267-74}
}
A large amount of data indicates that non-coding RNAs represent more than the "dark matter" of the genome. Both microRNAs and long non-coding RNAs are involved in several fundamental biologic processes, and their deregulation may lead in oncogenesis. Interacting with the Polycomb-repressive complex 2 subunit EZH2, they could affect the expression of protein-coding genes and form feedback networks and autoregulatory loops. They can also form networks with upstream and downstream important… CONTINUE READING

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