Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

  title={Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs},
  author={A. Gregory Matera and Rebecca M. Terns and Michael P. Terns},
  journal={Nature Reviews Molecular Cell Biology},
Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc)RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function. The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for… 

Biology and applications of small nucleolar RNAs

Small nucleolar RNAs (snoRNAs) constitute a group of non-coding RNAs principally involved in posttranscriptional modification of ubiquitously expressed ribosomal and small nuclear RNAs. However, a

Structured non-coding RNAs and the RNP Renaissance.

An Introduction to Small Non-coding RNAs: miRNA and snoRNA

This review provides an introduction to the biology of small ncRNA, using microRNA (miRNA) and small nucleolar RNA (snoRNA) as examples.

Regulatory Non-Coding RNAs: An Overview.

This introductive review provides a very concise historical and functional overview of most prominent small regulatory non-coding RNA families.

Small non-coding RNAs: a quick look in the rearview mirror.

A very succinct historical and functional overview on most prominent small non-coding RNA families is provided.

Regulation of alternative splicing by short non-coding nuclear RNAs

Current knowledge of this emerging class of RNAs is reviewed and evidence that some of these short RNAs could function in alternative splice site selection is discussed, suggesting intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events.

Elements and machinery of non‐coding RNAs: toward their taxonomy

This review catalogs and discusses representative small and long non‐coding RNA classes, focusing on their currently known (and unknown) RNA elements and RNP machineries.

Fragments of Small Nucleolar RNAs as a New Source for Noncoding RNAs

Small nucleolar RNAs (snoRNAs) are small, nonprotein-coding RNAs that accumulate in the nucleolus. So far, these RNAs have been implicated in modification of rRNAs, tRNAs, and snRNAs. snoRNAs can be



Biogenesis of small nucleolar ribonucleoproteins.

Non-coding-RNA regulators of RNA polymerase II transcription

Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are extremely diverse, which indicates

Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.

The recent discovery that homologs of snoRNAs as well as associated proteins exist in the domain Archaea indicates that the RNA-guided RNA modification system is of ancient evolutionary origin.

RNA-quality control by the exosome

Insight is provided into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.

An abundance of RNA regulators.

Current knowledge of regulatory RNA function is discussed and how the RNAs have been identified in a variety of organisms are reviewed to review how they act through base-pairing interactions with target RNAs.

The principles of guiding by RNA: chimeric RNA–protein enzymes

The non-protein-coding transcriptional output of the cell is far greater than previously thought and common features of these RNAs provide clues about the evolutionary constraints that led to the development of RNA-guided proteins and the specific biological environments in which target specificity and diversity are most crucial to the cell.

Non-coding RNAs: hope or hype?

A common maturation pathway for small nucleolar RNAs.

These results demonstrate that Box D, a conserved sequence element found in these and most other snoRNAs, plays a key role in their nuclear retention, 5′ cap hypermethylation and stability, and raises the possibility that a single nuclear hypermethylase activity may act on both nucleolar and spliceosomal snRNPs.