Non-coding-RNA regulators of RNA polymerase II transcription

@article{Goodrich2006NoncodingRNARO,
  title={Non-coding-RNA regulators of RNA polymerase II transcription},
  author={James A. Goodrich and Jennifer F. Kugel},
  journal={Nature Reviews Molecular Cell Biology},
  year={2006},
  volume={7},
  pages={612-616}
}
  • J. Goodrich, J. Kugel
  • Published 1 August 2006
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are extremely diverse, which indicates that, so far, we have only had a glimpse of this new class of regulatory factor. Many surprises are likely to be revealed as further ncRNA transcriptional regulators are identified and characterized. 
The expanding RNA polymerase III transcriptome.
The role of RNA polymerase (Pol) III in eukaryotic transcription is commonly thought of as being restricted to a small set of highly expressed, housekeeping non-protein-coding (nc)RNA genes. Recent
Evolution and Functions of Long Noncoding RNAs
TLDR
The evolution of long noncoding RNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease are reviewed.
6S RNA: a regulator of transcription
TLDR
The past decade has seen an explosion in discovery of small, non‐coding RNAs in all organisms, and a multitude of RNAs target mRNAs for regulation at the level of translation or stability, including the microRNAs in higher eukaryotes and the Hfq binding RN as in bacteria.
6S RNA: a small RNA regulator of transcription.
  • K. Wassarman
  • Biology, Medicine
    Current opinion in microbiology
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TLDR
The bacterial 6S RNA was the first sRNA shown to inhibit transcription by binding directly to the housekeeping holoenzyme form of RNA polymerase (i.e. sigma70-RNA polymerase in E. coli).
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This review focuses on the current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs, microRNAs,MicroRNAs and Piwi-interacting RNAs and their potential to be exploited as therapeutic agents.
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Current understanding and questions regarding the roles of small RNAs in regulating transcription are discussed.
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The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for understanding the biogenesis of other nc RNPs.
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The role that noncoding RNAs play as potent and specific regulators of gene expression is now widely recognized in almost all species studied to date.
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TLDR
The bacterial transcriptional repressor 6S RNA mimics the DNA contained in a melted promoter and forms specific interactions with the active site of RNA polymerase, which liberates the polymerase from 6SRNA.
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