Non-coding RNA in fly dosage compensation.

  title={Non-coding RNA in fly dosage compensation.},
  author={Xinxian Deng and Victoria H. Meller},
  journal={Trends in biochemical sciences},
  volume={31 9},
Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the… CONTINUE READING

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