Non-clonability correlates with genomic instability: a case study of a unique DNA region.

@article{Razin2001NonclonabilityCW,
  title={Non-clonability correlates with genomic instability: a case study of a unique DNA region.},
  author={Sergey V Razin and Elena S. Ioudinkova and Edward N. Trifonov and Klaus Scherrer},
  journal={Journal of molecular biology},
  year={2001},
  volume={307 2},
  pages={481-6}
}
Instability of eukaryotic DNA in constructs propagated in prokaryotic hosts is a frequently observed phenomenon. With the exception of a very high A+T-content and the presence of multiple repetitions, no general rule at the basis of this phenomenon is actually known. The intergenic spacer located between the pi and alpha(D) chicken alpha-type globin genes… CONTINUE READING