Non-classical HLA-E gene variability in Brazilians: a nearly invariable locus surrounded by the most variable genes in the human genome.

@article{VeigaCastelli2012NonclassicalHG,
  title={Non-classical HLA-E gene variability in Brazilians: a nearly invariable locus surrounded by the most variable genes in the human genome.},
  author={Luciana Caricati Veiga-Castelli and Erick C Castelli and Celso Texeira Mendes and Waldir Antonio da Silva and Margaux Faucher and Karine Beauchemin and M. Roger and Philippe Moreau and Eduardo Ant{\^o}nio Donadi},
  journal={Tissue antigens},
  year={2012},
  volume={79 1},
  pages={
          15-24
        }
}
The non-classical human leukocyte antigen (HLA) class I genes present a very low rate of variation. So far, only 10 HLA-E alleles encoding three proteins have been described, but only two are frequently found in worldwide populations. Because of its historical background, Brazilians are very suitable for population genetic studies. Therefore, 104 bone marrow donors from Brazil were evaluated for HLA-E exons 1-4. Seven variation sites were found, including two known single nucleotide… CONTINUE READING
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