Non-classic characteristics define prominent DNase activities from the intestine and other tissues of Haemonchus contortus.

@article{Kwak2003NonclassicCD,
  title={Non-classic characteristics define prominent DNase activities from the intestine and other tissues of Haemonchus contortus.},
  author={Dongmi Kwak and Douglas P. Jasmer},
  journal={Experimental parasitology},
  year={2003},
  volume={104 3-4},
  pages={
          131-9
        }
}
The anthelmintic fenbendazole (FBZ) induces nuclear DNA fragmentation (DF) in intestinal cells of Haemonchus contortus. The DNA fragments had 3'-OH, which suggests involvement of a neutral DNase. To identify candidate DNase(s) involved, DNase activity in H. contortus intestine and other worm fractions was characterized relative to classic DNases I (neutral) and II (acidic). Seven distinct DNase activities were identified and had Mrs of 34, 36, 37 or 38.5 kDa on zymographic analysis. The… CONTINUE READING
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