Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells

@article{Kizana2009NoncellautonomousEO,
  title={Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells},
  author={Eddy Kizana and Eugenio Cingolani and Eduardo Marb{\'a}n},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={1163-1168}
}
In mammalian cells, small regulatory RNA molecules are able to modulate gene expression in a cell-autonomous manner. In contrast, this mechanism of gene regulation can occur systemically in plants and nematodes. The existence of similar cell-to-cell transmission in mammalian cells has been explored, but generalizibilty and mechanistic insights have remained elusive. Here, we show that small regulatory RNA molecules are capable of a non-cell-autonomous effect between primary cardiac myocytes… CONTINUE READING
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