Non-catalytic domains of subunit A negatively regulate the activity of calcineurin.

@article{Liu2005NoncatalyticDO,
  title={Non-catalytic domains of subunit A negatively regulate the activity of calcineurin.},
  author={Ping Liu and Chao Huang and Zongchao Jia and Fang Yi and Da-yu Yu and Qun Wei},
  journal={Biochimie},
  year={2005},
  volume={87 2},
  pages={
          215-21
        }
}
Calcineurin is composed of a catalytic subunit A (CNA) and a regulatory subunit B (CNB). In addition to the catalytic core, CNA further contains three non-catalytic domains--CNB binding domain (BBH), calmodulin binding domain (CBD), and autoinhibitory domain (AI). To investigate the effect of these three domains on the activity of CNA, we have constructed domain deletion mutants CNAa (catalytic domain only), CNAac (CNAa and CBD), and CNAaci (CNAa, CBD and AI). By using p-nitrophenylphosphate… CONTINUE READING
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